ISO 22916:2022 pdf download.Microfluidic devices — Interoperability requirements for dimensions, connections and initial device classification
This document specifies requirements for the seamless integration with other microfluidic components and systems to facilitate the process of designing new microfluidic devices (e.g. microfluidic chips, sensors, actuators, connectors). This document is applicable to devices in the field of “microfluidics” needing microfluidic interconnections.
2 Normative references
The following documents are referred to in the text in such a way that some or all of their content constitutes requirements of this document. For dated references, only the edition cited applies. For undated references, the latest edition of the referenced document (including any amendments) applies.
ISO 10991, Micro process engineering — Vocabulary
3 Terms and definitions
For the purposes of this document, the terms and definitions given in ISO 10991 apply.
ISO and IEC maintain terminological databases for use in standardization at the following addresses:
— ISO Online browsing platform: available at https:// www .iso .org/ obp
— IEC Electropedia: available at https:// www .electropedia .org/
4 General dimension tolerances
Table 1 and Table 2 present the recommended general dimension tolerances regarding port pitches,chip thicknesses and port dimensions respectively for top connections and for side connections. In the tables and in the document n is an integer ≥1.
5 Chip reference point and topology
5.1 Chip topology
The chip is a flat microfluidic device. Figure 1 describes the names for each side of the chip.
5.2 Naming of the chip
The name of a rectangular (or square) chip shall contain information about the length and the width,defining an X-axis and a Y-axis. The X-axis shall be the direction with most of the fluidic connections.
Then, the name of the chip shall contain X × Y with the correct values.
EXAMPLE For a component of 15 mm by 30 mm with fluidic connections along the short length, the name of the chip contains at least 15 × 30. For example, “rectangular chip 15 × 30”.
5.3 Reference point
The reference point is the intersection of the X-axis and the Y-axis. With the X-axis pointing from left to right, the reference point is at the top left of the chip as described in Figure 2.
When a chip has rounded corners, the intersection of the extensions of X-axis and Y-axis shall be used as the reference point.
6 Microfluidic chip dimensions
6.1 Chip thickness
When made of glass, the microfluidic chip shall have a thickness compatible with existing standard wafer thicknesses since they are readily available and cheaper and no polishing is required. Moreover, standard wafers have an excellent surface quality, which has a positive influence in manufacturability and yield.
When made of polymer, the microfluidic chip should have a thickness between 1 mm and 3 mm and the microfluidic film shall have a thickness between 100 µm and 250 µm.
NOTE 1 The thickness is of relevance for side connection (see Clause 8).
NOTE 2 The usual thicknesses for bottom layer, t 1 , and top layer, t 2 , are given in Table 3.
The feasibility of the specific design and application should be checked regarding the compatibility of a device with a ‘t 1 ’ layer thickness thinner than 0,4 mm. The recommended minimum thickness for t 1 and t 2 is 0,4 mm but it also depends on the type of connector available.
6.2 Outer chip dimensions for microplate compatibility To be compatible with microplates format [2] , the microfluidic chip should have the outer dimensions given in Table 4 and illustrated in Figure 4. The distance (A; B) of the first hole from the reference point depends on the number of wells [3] .
6.3 Outer chip dimensions for microscope slide compatibility
The microfluidic chip should be rectangle with the outer dimensions given in Table 5.
A slide format that fits best to the grid of 1,5 mm, which is therefore the 25,5 mm × 75,0 mm slide format, is recommended, see Table 6.ISO 22916 pdf download.ISO 22916 pdf download
